The convent of Saint Francis, not far from the Palazzo Barberini in Palestrina, is one of the most important examples of Franciscan architecture in the Province of Rome.
It dates back to 1426 when a religious community of Franciscans decided to settle here. In 1637, Pope Urban VIII handed the convent over to a community of Reformed monks, the establishment of which encouraged the growth of the convent.
Its increasing importance led to a series of restoration and extension works. In 1875 the convent was confiscated from the declined Papal State, but was soon bought back by the order of Reformed Franciscans. The convent was renovated in 1972.

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